Lactate dehydrogenase and glucose-6 phosphate dehydrogenase activities in the testes of adult male Wistar rats following the administration of ethanol

Abstract

The present study was designed to evaluate the effects of the administration of ethanol on glucose-6-phosphate dehydrogenase (G-6PDH) and lactate dehydrogenase (LDH) levels in the testes of adult male wistar rats. Sixteen (16) adult male wistar rats weighing between 180 – 200g were divided into three groups A, and B of eight animals each.  In Group B each animal  were given 1ml of 15% ethanol daily while control group (Group A) were given the same ml (1ml) of phosphate buffered saline orally for a period of 21 days, at the end of which the animals were sacrificed and their testis assayed spectrophotometrically for the activities of G-6PDH and LDH. There was a significant (p<0.05) increase in G-6-PDH and LDH enzyme activities in the administered groups. The results indicate that administration of ethanol which is widely consumed alters carbohydrate metabolism in the testicular tissue.