A new mitochondrial theory of ageing subsumes apoptosis

Abstract

ABSTRACT: This new Mitochondria theory of ageing encapsulates most of the previous theories on ageing. The explosion of knowledge available from the Molecular Biology of Mitochondria biogenesis furnished an avalanche of Biochemical information, including the location of the long-souight-for, LONGEVITY GENE, which is now located in the Mitochondria. This recent discovery singles out mitochondrion as a BIOMARKER OF AGEING.

    ‘New Mitochodrial Theory of Ageing’ is pivoted on Mitochondrial Molecular Biology and Biochemistry particularly as they relate to mitochondrial biogenesis. The highpoint of the theory revolves around the roles of “Mitochondrial genome” as well as the in-situ production of “mitochondrial free radicals” in proportion to ingested calories from diets which precipitate such damages afflicting the genome (DNA and RNAS) primarily and other molecules secondarily resulting in molecular mayhem and gradual functional dysfunctions which culminate in ageing.

     Apoptotic proteins results from error-laden mitochondrial genomics  and proteomics Wyllie(1972) correctly observed and described “apoptosis” which is the down-stream” of this new mitochondrial theory of ageing .Recent advances in Molecular Biology of Mitochondria  revealed the whole “gamut” of processes in ageing. It culminated in the discovery of “longevity gene” in 2003. Hence, this new mitochondrial theory of ageing subsumes apoptosis-whereas apoptosis itself was the tip of the ice-berg of cell-death. Therefore, this new mitochondrial theory of ageing, is the whole iceberg on ageing, and thus a new mitochondrial theory hereby postulated and described in details.