Effect of consumption of charcoal-broiled beef on body weight and antioxidant status in rats

Abstract

In this study, the effects of sun-dried and charcoal-broiled beef compounded diets and their vitamin A supplemented versions on the antioxidant status in the liver were examined. Also examined was the effect of the same diets on the body and organ weights of the rats. The rats were in five experimental groups according to various diets and vitamin A supplemented version of the diets. The rats were given 0.8 g feed/g average group body weight in terms of feed for 14 days. The vitamin A supplements were administered to the rats by gavage at a dose of 400 IU units daily for 14 days. After 14 days, charcoal-broiled beef compounded diet only produced significant (P < 0.05) increase in malondialdehyde (MDA) in the liver compared to rats given sun-dried beef compounded diet only. Administering vitamin A supplements in addition to the charcoal-broiled beef compounded diet led to a significant decrease in MDA levels compared to rats given just the compounded diet.
Rats which received broiled beef diet only, had a higher liver-to-body weight ratio relative to other treatment groups. Rats given charcoal-broiled beef compounded diet only also showed retarded growth in the mean group
weight, with the growth improved in rats given supplemented version of the diet. The results presented here show that regular consumption of broiled beef leads to the production of bioactive metabolites or compounds
which increases lipid peroxidation in the liver in rats, and also leads to retarded growth with vitamin A supplements reversing these effects.